Effects of Mali Nil Surin (Mali Dam 2) Rice Bran Hydrolysate on Diabetic Rats
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Abstract
Mali Nil Surin (Mali Dam 2) is a non-glutinous rice variety with a black pericarp which contains higher levels of phenol antioxidants to prevent free radicals and serve potentially as nature-derived treatment against many non-communicable diseases, such as type 2 diabetes (T2D). The research aims to study the effect of Mali Nil Surin rice bran hydrolysate (RBH) on blood glucose level and the insulin resistance. To investigate antidiabetic activity, the laboratory rats were made chronically hyperglycemia feeding high fat-high fructose diet (HFFD) in compared with distilled water (normal control) for 10 weeks. Then the diabetic rats were given distilled water (HFFD control), RBH (100 or 300 mg/kg body weight per day) and Pioglitazone (drug treatment of T2D) over a 6-week period. Body weight, fasting blood glucose (FBG), oral glucose tolerance test (OGTT), insulin resistance (HOMA-IR value) and hormone leptin were thoroughly evaluated. After six weeks, the diabetic rats (HFFD control) showed increasing in body weight, FBG, OGTT, insulin and leptin level, and HOMA-IR value comparing with the normal control. In addition, both doses of RBH could significantly lower the value of all these parameters compared to the HFFD-control, similar to that of Pioglitazone intake. However, the body weight gain in the RBH-fed as well as the Pioglitazone-fed were not different from HFFD-fed rats. In conclusion, the Mali Nil Surin rice RBH could be a useful nutraceutical to control the blood glucose levels. Hence, Mali Nil Surin rice should be accordingly considered to facilitate the prevention and treatment of type 2 diabetes.
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References
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